Many drugs can be administered in oral solid dose form as capsules, tablets, or chewable tablets. Because this route is the most convenient, usually the safest, and often least expensive, it is also the one most often used.1 However, in their development, there can be stability issues associated with moisture, oxygen and reactive impurities resulting in the loss of potency or degradant growth. Recently, new concerns related to potentially carcinogenic nitrosamines found in drug products have added another layer of complexity for drug developers. Aptar CSP Technologies’ proprietary 3-Phase Activ-Polymer™ platform technology can be deployed in multiple formats to protect sensitive API’s and assure patients receive accurate dosage. This technology enables the creation of a specific, optimized, microclimate for oral solid dose drugs in order to meet stability requirements and reduce or eliminate impurities like nitrosamines.
Activ-Blister™ Solutions provides drug product specific protection to address growing stability limitations in a blister packaging format. This innovative technology integrates Aptar’s proprietary 3-Phase Activ-Polymer™ film into each individual blister cavity to provide the ideal microclimate to protect tablets or capsules inside a thermoformed blister package.
Using highly-engineered 3-Phase Activ-Polymer™ technology, Activ-Blister™ can adsorb tailored amounts of water vapor, scavenge oxygen or VOCs, or provide a combination of active protection. Our latest innovation, N-Sorb, is engineered to prevent nitrosamine formation and reduce or eliminate nitrosamine molecules post formation. The technology can be fitted to accommodate any tablet or capsule size and is securely bound to the lid stock using our proprietary heat-staking technology.
Aptar’s Activ-Vial™ portfolio of solutions offers the next generation of oral solid dose protection in bottle or vial format. The integrated, molded 3-Phase Activ-Polymer™ lines the bottle or vial to provide superior protection against residual and external moisture or oxygen, as well as light, eliminating the need for limited-capacity sachets or canisters that are used with traditional desiccant packaging.
Aptar CSP’s Activ-Vial™ portfolio consists of one-piece, flip-top active vials and active bottles in a range of sizes. Both formats provide manufacturers various options to satisfy their packaging requirements while offering integrated moisture protection.